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Prokinetic agents such as metoclopramide or domperidone, which accelerate gastric emptying, may counteract some of the therapeutic effects of semaglutide on satiety and weight loss. Conversely, medications that further slow gastric emptying, such as anticholinergics or opioid analgesics, may exacerbate gastrointestinal adverse effects including nausea, vomiting, and constipation. The combination of multiple medications affecting gastrointestinal …
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